Phased-Mission Reliability and Importance Measure Analysis for Linear and Circular UAV Swarms

The phased-mission reliability of unmanned aerial vehicle (UAV) swarm refers to its capability to successfully complete the missions of each phase under specified conditions for a specified period. In order to study the reliability of phased-mission in UAV swarm, this paper firstly studies the reliability of a single UAV under fault coverage. Then, considering the mission characteristics of UAV swarm, the consecutive k-out-of-n system is studied to model and predict the reliability of UAV swarm phase mission. Some importance measures are introduced to analyze the influence of UAV in different positions on the reliability of the whole system. Finally, numerical examples of linear and circular UAV swarms are given to demonstrate and verify the correctness of the model. The reliability modeling established in this paper can predict the phased-mission reliability of UAV swarm scientifically

Flow field and noise characteristics of manifold in natural gas transportation station

International audienceManifolds play a role of pressure balance, buffering and rectification for different branch pipelines, the flow noise of manifolds has been a serious problem all this time in natural gas transmission station. By changing the number of outlet pipes of manifolds and the different positions of intake pipes, the distribution of the Sound Pressure Level (SPL) of the manifold flow noise is analyzed based on the Ffowcs Williams-Hawkings (FW-H) acoustic analogy theory and Large Eddy Simulations (LESs). The three-dimensional simulation analysis of the flow field shows that pressure pulsation is the mainly source of manifold noise, as the number of outlet pipe increases, the SPLs of fluid dynamic noise at the end of inlet pipes are significantly reduced by about 10 dB on average, when the inlet and outlet piping are oppositely connected, the SPL is 2 dB~3 dB lower than that in staggered connections. An expansion-chamber muffler is designed with the analysis of its noise reduction effect, the results show that after the muffler is installed, the noise reduction in the low-frequency ranges reaches up to 37.5 dB, which controls the maximum noise to around 82 dB

Evidence of the Efficacy and the Effectiveness of First Generation COVID-19 Vaccines in Clinical Trials and Real-world Studies

More than 300 COVID-19 vaccine candidates have been developed or are currently in development. COVID-19 vaccines on the World Health Organization’s Emergency Use Listing and other COVID-19 vaccine products conditionally approved by national regulatory authorities are already in large-scale use, thus preventing severe illness or death and inducing herd immunity at the population level in the SARS-CoV-2 pandemic. In this review, we systemically assess the efficacy and effectiveness of COVID-19 vaccines in clinical trials or real-world studies, in various populations, including healthy adults, children, older people, pregnant people, people with cancer, and people receiving long-term hemodialysis or solid organ transplantation. In addition, we review available evidence regarding the effectiveness of COVID-19 vaccine immunization strategies in people with a history of SARS-CoV-2 infection, and the enhanced effectiveness conferred by various booster immunizations. We also discuss knowledge gaps in the persistence and spectrum of vaccine protection of currently available COVID-19 vaccines

Creation of an Industrial Bacillus thuringiensis Strain With High Melanin Production and UV Tolerance by Gene Editing

Bacillus thuringiensis produces insecticidal crystal proteins (ICPs) which exhibit strong insecticidal toxicity. But when used in the field, ICPs would be destroyed by ultraviolet (UV) radiation in sunlight, thus decreasing the insecticidal activity and shortening the persistence. To improve the duration of B. thuringiensis preparations, we endowed a highly toxic industrial B. thuringiensis HD-1 with UV tolerance by making it produce melanin, a pigment that absorbs UV radiation. In B. thuringiensis, melanin is derived from homogentisate (HGA), an intermediate in the tyrosine pathway. And the absence of homogentisate-1,2-dioxygenase (HmgA) will lead to the formation of melanin. In this study, we used the CRISPR/Cas9 system to knock out the hmgA gene and obtained a melanin-producing mutant HD-1-ΔhmgA from strain HD-1. The melanin yield by mutant HD-1-ΔhmgA reached 3.60 mg/mL. And the anti-UV test showed that melanin serves as a protection to both the organism and the ICPs. After UV irradiation for 3 h, mutant HD-1-ΔhmgA still had an 80% insecticidal activity against the cotton bollworm, Helicoverpa armigera, while the control line only had about 20%. This study creates a light-stable biopesticide prototype based on a classic industrial strain that can be applied directly and takes the melanin-producing strain as a concept to improve the preparation validity

Greedy search method for separable nonlinear models using stage Aitken gradient descent and least squares algorithms

Aitken gradient descent (AGD) algorithm takes some advantages over the standard gradient descent (SGD) and Newton methods: (1) can achieve at least quadratic convergence in general; (2) does not require the Hessian matrix inversion; (3) has less computational efforts. When using the AGD method for a considered model, the iterative function should be unchanging during all the iterations. This paper proposes a hierarchical AGD algorithm for separable nonlinear models based on stage greedy method. The linear parameters are estimated using the least squares algorithm, and the nonlinear parameters are updated based on the AGD algorithm. Since the iterative function is changing at each iteration, a stage AGD algorithm is introduced. The convergence properties and simulation examples show effectiveness of the proposed algorithm

Prevalence of workplace violence against healthcare workers: a systematic review and meta-analysis

We aim to quantitatively synthesise available epidemiological evidence on the prevalence rates of workplace violence (WPV) by patients and visitors against healthcare workers. We systematically searched PubMed, Embase and Web of Science from their inception to October 2018, as well as the reference lists of all included studies. Two authors independently assessed studies for inclusion. Data were double-extracted and discrepancies were resolved by discussion. The overall percentage of healthcare worker encounters resulting in the experience of WPV was estimated using random-effects meta-analysis. The heterogeneity was assessed using the I2 statistic. Differences by study-level characteristics were estimated using subgroup analysis and meta-regression. We included 253 eligible studies (with a total of 331 544 participants). Of these participants, 61.9% (95% CI 56.1% to 67.6%) reported exposure to any form of WPV, 42.5% (95% CI 38.9% to 46.0%) reported exposure to non-physical violence, and 24.4% (95% CI 22.4% to 26.4%) reported experiencing physical violence in the past year. Verbal abuse (57.6%; 95% CI 51.8% to 63.4%) was the most common form of non-physical violence, followed by threats (33.2%; 95% CI 27.5% to 38.9%) and sexual harassment (12.4%; 95% CI 10.6% to 14.2%). The proportion of WPV exposure differed greatly across countries, study location, practice settings, work schedules and occupation. In this systematic review, the prevalence of WPV against healthcare workers is high, especially in Asian and North American countries, psychiatric and emergency department settings, and among nurses and physicians. There is a need for governments, policymakers and health institutions to take actions to address WPV towards healthcare professionals globally

Conservation tillage increases corn and soybean water productivity across the Ohio River Basin

Optimizing agricultural management practices is imperative for ensuring food security and building climate-resilient agriculture. The past several decades have witnessed the emergence of conservation tillage practices to combat soil erosion and degradation. However, the effects of conservation tillage on crop water productivity (CWP) remain uncertain, especially from a regional-scale perspective. Here, we used an improved process-based agroecosystem model (DLEM-Ag) to quantify the long-term effects of conservation tillage (e.g., no-tillage, NT; reduced tillage, RT) on CWP (defined as the ratio of crop productivity to evapotranspiration) of corn and soybean across the Ohio River Basin during 1979–2018. Our results revealed an average increase of 2.8% and 8.4% in CWP for corn and soybean, respectively, under the NT adoption scenario. Compared to the conventional tillage scenario, NT and RT would enhance CWP, primarily due to reductions in evapotranspiration, particularly evaporation. Further analysis suggested that, although NT and RT may decrease surface runoff, these practices could also increase subsurface drainage and nutrient loss from corn and soybean farmland via leaching. These results indicate that conservation tillage should be complemented with additional water and nutrient management practices to enhance soil water retention and optimize nutrient use in the region's cropland. Our findings also provide unique insights into optimizing management practices for other areas where conservation tillage is widely applied

Altered spontaneous brain activity during dobutamine challenge in healthy young adults: A resting-state functional magnetic resonance imaging study

IntroductionThere is a growing interest in exploring brain-heart interactions. However, few studies have investigated the brain-heart interactions in healthy populations, especially in healthy young adults. The aim of this study was to explore the association between cardiovascular and spontaneous brain activities during dobutamine infusion in healthy young adults.MethodsForty-eight right-handed healthy participants (43 males and 5 females, range: 22–34 years) underwent vital signs monitoring, cognitive function assessment and brain MRI scans. Cardiovascular function was evaluated using blood pressure and heart rate, while two resting-state functional magnetic resonance imaging (rs-fMRI) methods—regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF)—were used together to reflect the local neural activity of the brain. Logistic regression was used to model the association between brain and heart.ResultsResults showed that blood pressure and heart rate significantly increased after dobutamine infusion, and the performance in brain functional activity was the decrease in ReHo in the left gyrus rectus and in ALFF in the left frontal superior orbital. The results of logistic regression showed that the difference of diastolic blood pressure (DBP) had significant positive relationship with the degree of change of ReHo, while the difference of systolic blood pressure (SBP) had significant negative impact on the degree of change in ALFF.DiscussionThese findings suggest that the brain-heart interactions exist in healthy young adults under acute cardiovascular alterations, and more attention should be paid to blood pressure changes in young adults and assessment of frontal lobe function to provide them with more effective health protection management

Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis

Angiogenesis, a key step in many physiological and pathological processes, involves proteolysis of the extracellular matrix. To study the role of two enzymatic families, serine-proteases and matrix metalloproteases in angiogenesis, we have adapted to the mouse, the aortic ring assay initially developed in the rat. The use of deficient mice allowed us to demonstrate that PAI-1 is essential for angiogenesis while the absence of an MMP, MMP-11, did not affect vessel sprouting. We report here that this model is attractive to elucidate the cellular and molecular mechanisms of angiogenesis, to identify, characterise or screen "pro- or anti-angiogenic agents that could be used for the treatment of angiogenesis-dependent diseases. Approaches include using recombinant proteins, synthetic molecules and adenovirus-mediated gene transfer